Tripathi R C, Pandey S K, Kar K, Dikshit M, Saxena A K
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Bioorg Med Chem Lett. 1999 Sep 20;9(18):2693-8. doi: 10.1016/s0960-894x(99)00456-4.
Synthesis and SAR studies of the title compounds have resulted in the identification of structural and physicochemical parameter (Vw) contributing for antiarrhythmic activity. Among the two most promising compounds 3a & 3b, the 3a has shown antiarrhythmic activity comparable to quinidine.
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