Caudry M, Bonnel C
Service de cancérologie, hôpital Saint-André, Bordeaux, France.
Rev Med Interne. 1999 Sep;20(9):810-5. doi: 10.1016/s0248-8663(00)88690-7.
Pancreatic carcinoma is a major public health concern, as it kills more than 6,000 people each year in France.
The main risk factor demonstrated by concordant case-control studies is cigarette smoking. Pancreatic carcinoma is generally diagnosed at an advanced stage. Results of radical surgery are still poor. In most of the reported series, less than 25% of the patients survive at five years.
Postoperative radiochemotherapy slightly increases the hope of cure. In locally advanced tumors, radiochemotherapy, sometimes preoperative, allows some patients to survive more than two years. Though results of palliative chemotherapy remain very poor, some clinical benefit has been observed in randomized trials comparing this treatment with the currently best supportive treatment.
胰腺癌是一个重大的公共卫生问题，在法国每年有超过6000人死于该病。
一致的病例对照研究表明，主要风险因素是吸烟。胰腺癌通常在晚期被诊断出来。根治性手术的效果仍然很差。在大多数报道的系列研究中，不到25%的患者能存活五年。
术后放化疗略微增加了治愈的希望。在局部晚期肿瘤中，放化疗（有时是术前放化疗）能使一些患者存活超过两年。尽管姑息化疗的效果仍然很差，但在将这种治疗与目前最佳支持治疗进行比较的随机试验中已观察到一些临床益处。
