Ha J C, Kim S Y, Lee Y M
Department of Industrial Chemistry, College of Engineering, Hanyang University, Seoul, South Korea.
J Control Release. 1999 Dec 6;62(3):381-92. doi: 10.1016/s0168-3659(99)00167-4.
Amphiphilic block copolymers based on PEO-PPO-PEO block copolymer (Pluronic) and poly(epsilon-caprolactone) were synthesized by bulk polymerization. The structural analysis of Pluronic/PCL block copolymer was carried out using FT-IR, 1H NMR, GPC, WAXD, DSC and TGA measurements. To prepare copolymeric nanospheres with a micellar structure, Pluronic/PCL amphiphilic block copolymers were dialyzed against water. The size and size distribution of Pluronic/PCL block copolymeric nanospheres were examined by dynamic light scattering measurement. They showed an average diameter of 116 to 196 nm depending on the type of copolymer. All the nanosphere samples exhibited a narrow size distribution. The critical micelle concentrations of Pluronic/PCL amphiphilic block copolymers determined by fluorescence spectroscopy were lower than that of common low molecular weight surfactants. We confirmed the formation of stable copolymeric nanospheres through the solution behavior of amphiphilic block copolymer in selective solvents.
通过本体聚合法合成了基于聚环氧乙烷-聚环氧丙烷-聚环氧乙烷嵌段共聚物（普朗尼克）和聚（ε-己内酯）的两亲性嵌段共聚物。使用傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（¹H NMR）、凝胶渗透色谱（GPC）、广角X射线衍射（WAXD）、差示扫描量热法（DSC）和热重分析法（TGA）对普朗尼克/聚己内酯嵌段共聚物进行结构分析。为制备具有胶束结构的共聚物纳米球，将普朗尼克/聚己内酯两亲性嵌段共聚物对水进行透析。通过动态光散射测量法检测普朗尼克/聚己内酯嵌段共聚物纳米球的尺寸和尺寸分布。根据共聚物类型的不同，它们的平均直径为116至196纳米。所有纳米球样品均呈现窄尺寸分布。通过荧光光谱法测定的普朗尼克/聚己内酯两亲性嵌段共聚物的临界胶束浓度低于常见的低分子量表面活性剂。我们通过两亲性嵌段共聚物在选择性溶剂中的溶液行为证实了稳定共聚物纳米球的形成。
