Matrisian L M
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA.
Curr Biol. 1999 Oct 21;9(20):R776-8. doi: 10.1016/S0960-9822(00)80011-1.
Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in transgenic mice.