Korhonen K, Kuttila K, Niinikoski J
Department of Surgery, University of Turku, Finland.
Eur J Surg. 1999 Sep;165(9):885-90. doi: 10.1080/11024159950189401.
To investigate the response of subcutaneous tissue oxygen (O2) and carbon dioxide (CO2) tensions to hyperbaric oxygenation.
Experimental study.
University hospital, Finland.
10 Wistar rats.
Subcutaneous tissue PO2 and PCO2 were directly measured with an implanted Silastic tube tonometer and capillary sampling technique while breathing air and exposed to hyperbaric oxygen (HBO) at 2.5 or 2.8 ATA pressure. Hyperbaric exposures were carried out in a large multiplace chamber pressurised with air.
Subcutaneous tissue PO2 and PCO2.
The mean subcutaneous PO2 rose from the baseline of 8 kPa (60 mmHg) to 16 kPa (112 mmHg) when rats breathed room air during pressurisation to 2.8 atm. When the rats breathed oxygen at 2.5 ATA the maximal mean tissue PO2 was four times higher than the mean starting value. During the HBO treatment at 2.8 ATA the tissue PO2 rose to a value about five times above baseline. The tissue PCO2 values almost doubled during the exposure to HBO at 2.5 ATA, probably because elimination of carbon dioxide was impaired.
Measurements of tissue PO2 and PCO2 with an implanted Silastic tonometer and a capillary sampling technique can successfully be adapted to hyperbaric conditions. The method yielded reproducible results and is applicable to clinical use in hyperbaric medicine.
研究皮下组织氧（O2）和二氧化碳（CO2）张力对高压氧疗的反应。
实验研究。
芬兰大学医院。
10只Wistar大鼠。
在大鼠呼吸空气并暴露于2.5或2.8ATA压力的高压氧（HBO）环境下时，使用植入的硅橡胶管压力计和毛细管采样技术直接测量皮下组织的PO2和PCO2。高压暴露在一个用空气加压的大型多人舱中进行。
皮下组织PO2和PCO2。
当大鼠在加压至2.8个大气压时呼吸室内空气，皮下平均PO2从基线的8kPa（60mmHg）升至16kPa（112mmHg）。当大鼠在2.5ATA呼吸氧气时，最大平均组织PO2比平均起始值高四倍。在2.8ATA的高压氧治疗期间，组织PO2升至基线以上约五倍的值。在2.5ATA的高压氧暴露期间，组织PCO2值几乎翻倍，可能是因为二氧化碳的消除受到损害。
使用植入的硅橡胶压力计和毛细管采样技术测量组织PO2和PCO2能够成功地适应高压环境。该方法产生了可重复的结果，适用于高压医学的临床应用。
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