未针对风险因素进行筛选的意大利人群中的丙型肝炎感染情况。

Hepatitis C infection in an Italian population not selected for risk factors.

作者信息

Maggi G, Armitano S, Brambilla L, Brenna M, Cairo M, Galvani G, Gola D, Komla-Ebri K, Marmondi E, Perricone G, Posca M, Vegezzi P G, Vergani C, De Leo G

机构信息

Divisione Medica, FBF, Erba, Italy.

出版信息

Liver. 1999 Oct;19(5):427-31. doi: 10.1111/j.1478-3231.1999.tb00073.x.

DOI:10.1111/j.1478-3231.1999.tb00073.x

PMID:10533802

Abstract

AIMS/BACKGROUND: This study estimated the prevalence of HCV infection and relationship with viremia in a general population. The inhabitants of Albavilla town were personally invited to participate.

METHODS

Out of 3997 inhabitants falling within the age range 18-85 years, 2403 (participation rate 60.1%) were examined for transaminases, HCVAb, HCVRNA, genotype and immunoblot assay. The following information was collected: sex, age, blood transfusions, surgery, use of glass syringes, drug addiction, alcohol consumption, tattoos and body mass index.

RESULTS

115 (4.8%) were HCVAb+, the prevalence being 1.2% under 40 years. Transfusion in the past was the only risk factor for HCV infection. Among the HCVAb+ subjects, 71 (61.7%) were HCVRNA+. 40.8% of the HCVAb+/HCVRNA+ group had normal ALT, compared with 68% of those with HCVAb+/HCVRNA-. The HCV genotypes in the 71 HCVRNA+ subjects were: 2a/2c in 58 (81.7%), 40% of them with normal ALT;1b in 11 (15.5%), none with normal ALT; genotype 3 in two (2.8%).

CONCLUSION

The prevalence of HCVAb in this general population was 4.8%. About 3% were HCVRNA positive and of these genotype 2a/ 2c was present in 81.6%.

摘要

目的/背景：本研究评估了普通人群中丙型肝炎病毒（HCV）感染的患病率及其与病毒血症的关系。阿尔巴维拉镇的居民被邀请亲自参与。

方法

在3997名年龄在18 - 85岁之间的居民中，2403人（参与率60.1%）接受了转氨酶、抗-HCV、HCV RNA、基因型和免疫印迹检测。收集了以下信息：性别、年龄、输血史、手术史、玻璃注射器使用情况、药物成瘾情况、饮酒情况、纹身情况和体重指数。

结果

115人（4.8%）抗-HCV阳性，40岁以下人群患病率为1.2%。既往输血是HCV感染的唯一危险因素。在抗-HCV阳性受试者中，71人（61.7%）HCV RNA阳性。抗-HCV阳性/HCV RNA阳性组中40.8%的人谷丙转氨酶（ALT）正常，而抗-HCV阳性/HCV RNA阴性组这一比例为68%。71名HCV RNA阳性受试者的HCV基因型为：58人（81.7%）为2a/2c型，其中40%的人ALT正常；11人（15.5%）为1b型，无人ALT正常；2人（2.8%）为3型。