增强4岁及以下支气管哮喘患者的茶碱代谢。
Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under.
作者信息
Kizu J, Arakawa M, Arakawa Y, Komoda F, Takamizawa M, Iwata T, Hayakawa T, Imai K
机构信息
Department of Pharmacy, Branch Hospital, Faculty of Medicine, University of Tokyo, 3-28-6 Mejirodai, Bunkyo-ku, Tokyo 112-8688, Japan.
出版信息
Biomed Chromatogr. 1999 Nov;13(7):462-4. doi: 10.1002/(SICI)1099-0801(199911)13:7<462::AID-BMC912>3.0.CO;2-P.
The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1-4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug-metabolizing enzymes during infancy.
对接受茶碱缓释制剂治疗的支气管哮喘患者测定了血浆中茶碱（TP）及其代谢产物的水平。1至4岁组中这些代谢产物的血浆水平与TP水平的比值高于5岁及以上组，提示婴儿期药物代谢酶活性增强。
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