Hauber J, Rein J G, Sigel H
Medizinische Klinik I, Klinik am Eichert, Göppingen.
Dtsch Med Wochenschr. 1999 Sep 24;124(38):1095-8. doi: 10.1055/s-2007-1024487.
A few days after uneventful surgical reconstruction of the mitral valve a 43-year-old man was found to have a systolic murmur due to prolapse of the posterior leaflet, suggesting renewed mitral regurgitation.
Echocardiography revealed haemodynamically significant left ventricular outflow tract obstruction (LVOT) with a left ventricle to aorta systolic gradient of 83 mm Hg. In addition there was moderately severe mitral regurgitation as well as a pericardial effusion but no signs of tamponade.
The obstruction was at first treated with verapamil, later with sotalol. The pericardial effusion was interpreted as part of a postcardiotomy syndrome. The effusion regressed under steroid administration, and the LVOT and mitral regurgitation also decreased. A provocation test five months postoperatively no longer brought about an outflow gradient. The good results were still present 12 months postoperatively.
The described, rarely seen form of LVOT was probably caused by a combination of a very large anterior mitral leaflet, postoperative pericardial effusion and pharmacological effects. If the obstruction first occurs postoperatively, appropriate medication may improve the cardiac status and reoperation may be avoided. Echocardiography is an important method of diagnosis and serial monitoring.
一名43岁男性在二尖瓣手术重建顺利完成几天后,被发现因后叶脱垂出现收缩期杂音,提示二尖瓣反流复发。
超声心动图显示存在具有血流动力学意义的左心室流出道梗阻(LVOT),左心室与主动脉之间的收缩期压差为83毫米汞柱。此外,还有中度严重的二尖瓣反流以及心包积液,但无心脏压塞迹象。
梗阻起初用维拉帕米治疗,后来用索他洛尔治疗。心包积液被认为是心脏切开术后综合征的一部分。在给予类固醇治疗后,积液消退,LVOT及二尖瓣反流也有所减轻。术后五个月的激发试验不再产生流出道压差。术后12个月仍保持良好效果。
所描述的这种罕见的LVOT形式可能是由非常大的二尖瓣前叶、术后心包积液及药物作用共同导致的。如果梗阻首次出现在术后,适当的药物治疗可能改善心脏状况并避免再次手术。超声心动图是诊断及连续监测的重要方法。