Isimbaldi G, Di Nuovo F, Sironi M, Catania G, Bonacina R, Privitera O, Spinelli M
Dipartimento di Patologia, Ospedale S. Corona, Garbagnate Milanese, Milano.
Pathologica. 1999 Jun;91(3):192-7.
Nephrogenic Adenoma (NA) is a rare lesion of the urinary tract, considered a metaplastic response to chronic inflammation, trauma or immunosuppression.
We report two cases of NA arising in the urinary bladder of patients with previous history of recurrent urinary tract infections due to neuropsychiatric disease. Pathological examination of the lesions, resected by transurethral (TUR) management, revealed a papillary proliferation of tubules and cysts lined by cuboidal to low-columnar cells without atypia. Immunohistochemistry showed positivity for Cam 5.2, CK7 and EMA. MIB 1 count demonstrated a positivity in 12/200 cells in case 1 and < 2/200 in case 2. No expression of nuclear p53 was evident.
NA is a benign unusual neoplasm which might be misdiagnosed as clear cell adenocarcinoma of the bladder or prostatic adenocarcinoma. Its recognition is important because it is a benign lesion cured by a conservative resection and no additional therapy is generally required.
肾源性腺瘤（NA）是一种罕见的泌尿道病变，被认为是对慢性炎症、创伤或免疫抑制的一种化生反应。
我们报告两例NA，发生于既往因神经精神疾病反复发生尿路感染的患者的膀胱。经尿道（TUR）处理切除的病变组织的病理检查显示，由立方状至低柱状细胞衬覆的小管和囊肿呈乳头状增生，无异型性。免疫组化显示Cam 5.2、CK7和EMA呈阳性。MIB 1计数显示，病例1中200个细胞中有12个呈阳性，病例2中<2个呈阳性。未发现核p53表达。
NA是一种良性的不常见肿瘤，可能被误诊为膀胱透明细胞腺癌或前列腺腺癌。认识到它很重要，因为它是一种通过保守切除即可治愈的良性病变，一般无需额外治疗。
