Backov R, Khan S R, Mingotaud C, Byer K, Lee C M, Talham D R
Department of Chemistry, University of Florida, Gainesville 32611-7200, USA.
J Am Soc Nephrol. 1999 Nov;10 Suppl 14:S359-63.
Studies of calcium oxalate monohydrate (COM) precipitation at Langmuir monolayers of the phospholipids dipalmitoylphosphatidylglycerol (DPPG), dipalmitoylphosphatidylcholine (DPPC), and dipalmitoylphosphatidylserine (DPPS) are reported. The precipitation is heterogeneous and selective, with a majority of crystals orienting with the COM (101) face toward the monolayer interface for each phospholipid. The number density of COM crystals depends on the identity of the phospholipid monolayer, decreasing in the order DPPG > DPPS > DPPC. It was also found that COM precipitation increases as the surface pressure of the monolayer is lowered and with the addition of low levels (<0.1%) of cholesterol. The possibility that changes in monolayer fluidity influence COM attachment is discussed.
本文报道了在二棕榈酰磷脂酰甘油（DPPG）、二棕榈酰磷脂酰胆碱（DPPC）和二棕榈酰磷脂酰丝氨酸（DPPS）的朗缪尔单分子层上草酸钙一水合物（COM）沉淀的研究。沉淀是不均匀且具有选择性的，对于每种磷脂，大多数晶体的COM（101）面朝向单分子层界面排列。COM晶体的数密度取决于磷脂单分子层的种类，按DPPG＞DPPS＞DPPC的顺序降低。还发现，随着单分子层表面压力的降低以及添加低水平（<0.1%）的胆固醇，COM沉淀增加。讨论了单分子层流动性变化影响COM附着的可能性。
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