训练核酶进行转换。
Training ribozymes to switch.
作者信息
Marshall K A, Ellington A D
机构信息
Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
Nat Struct Biol. 1999 Nov;6(11):992-4. doi: 10.1038/14872.
DOI:10.1038/14872
PMID:10542083
Abstract
Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes are specifically activated by a factor of 5,000 - the largest allosteric ribozyme activation by a small molecule seen to date.
摘要
对环核苷酸敏感的核酶已在体外被筛选出来。值得注意的是，依赖于环鸟苷酸的核酶被一种因子特异性激活了5000倍——这是迄今为止所观察到的由小分子引起的最大的变构核酶激活作用。
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