髓过氧化物酶抗中性粒细胞胞浆抗体阳性的坏死性新月体性肾小球肾炎和膜性肾小球病
Myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy.
作者信息
Taniguchi Y, Yorioka N, Kumagai J, Ito T, Yamakido M, Taguchi T
机构信息
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
出版信息
Clin Nephrol. 1999 Oct;52(4):253-5.
In September 1997, a 68-year-old woman was found to have proteinuria and renal dysfunction. In December 1997, renal biopsy revealed necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy. We diagnosed myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy because of the presence of necrotizing cellular crescents and spike lesions in the subepithelial region of the glomerular basement membrane. After steroid therapy, the antibody level and the incidence of cellular crescents showed a decrease. This is a rare case of myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis associated with membranous glomerulonephropathy.
1997年9月，一名68岁女性被发现存在蛋白尿和肾功能不全。1997年12月，肾活检显示为坏死性新月体性肾小球肾炎和膜性肾小球肾病。由于在肾小球基底膜上皮下区域存在坏死性细胞性新月体和钉突病变，我们诊断为髓过氧化物酶抗中性粒细胞胞浆抗体阳性的坏死性新月体性肾小球肾炎和膜性肾小球肾病。类固醇治疗后，抗体水平和细胞性新月体的发生率有所下降。这是一例罕见的髓过氧化物酶抗中性粒细胞胞浆抗体阳性的坏死性新月体性肾小球肾炎合并膜性肾小球肾病的病例。
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