Bernardo B D, Huettner P C, Merritt D F, Ratts V S
Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
J Pediatr Adolesc Gynecol. 1999 Aug;12(3):157-60. doi: 10.1016/s1038-3188(99)00010-8.
Calcinosis cutis is a general term for calcium deposition in the skin. It may be due to abnormal calcium or phosphorus metabolism, damage to the dermal collagen, or idiopathic. It has been found in the skin of many areas of the body, including the face, extremities, penis, scrotum and mons pubis. We report two cases of calcinosis cutis presenting as lesions of the labia majora in children.
A 6 1/2-year-old girl presented with labial lesions of unknown etiology. There was no history of sexual abuse or trauma. Excisional biopsy was performed and histopathological evaluation showed subepithelial calcification. Follow-up laboratory evaluation revealed normal serum calcium and phosphorus levels. Screening tests for collagen vascular diseases were negative. An 8-year-old girl presented for evaluation of a "labial cyst." The lesion was first noted 6 months prior to presentation and had not resolved, despite treatment with topical creams and sitz baths. Excisional biopsy was performed and histopathological evaluation showed multiple nodules of calcified and amorphous debris surrounded by histiocytes and giant cells.
We report two cases of idiopathic calcinosis cutis presenting as labial lesions in children. Because it can be mistaken for a sexually transmitted disease, recognition and proper diagnosis of this condition is essential. Additionally, work-up to rule out abnormalities of phosphorus or calcium metabolism and collagen vascular diseases may be indicated.
皮肤钙质沉着症是指钙在皮肤中的沉积的统称。其可能由于钙或磷代谢异常、真皮胶原蛋白损伤或特发性原因所致。在身体的许多部位的皮肤中都有发现，包括面部、四肢、阴茎、阴囊和耻骨联合。我们报告两例儿童大阴唇出现病变的皮肤钙质沉着症病例。
一名6岁半女童出现病因不明的唇部病变。无性虐待或外伤史。进行了切除活检，组织病理学评估显示上皮下钙化。后续实验室评估显示血清钙和磷水平正常。胶原血管疾病筛查试验为阴性。一名8岁女童因“唇部囊肿”前来评估。该病变在就诊前6个月首次被发现，尽管使用了外用乳膏和坐浴治疗，但仍未消退。进行了切除活检，组织病理学评估显示多个由组织细胞和巨细胞围绕的钙化和无定形碎片结节。
我们报告两例儿童特发性皮肤钙质沉着症表现为唇部病变。由于其可能被误诊为性传播疾病，识别和正确诊断这种疾病至关重要。此外，可能需要进行检查以排除磷或钙代谢异常以及胶原血管疾病。
