在体内，核小体定位独立于组蛋白H1。
Nucleosome positioning is independent of histone H1 in vivo.
作者信息
Karrer K M, VanNuland T A
机构信息
Department of Biology, Marquette University, Milwaukee, Wisconsin 53201-1881, USA. kathleen,
出版信息
J Biol Chem. 1999 Nov 12;274(46):33020-4. doi: 10.1074/jbc.274.46.33020.
PMID:10551870
Abstract
Nucleosome positioning in the somatic macronuclear genome of the ciliated protozoan Tetrahymena thermophila was analyzed by indirect end labeling. Nucleosomes were positioned nonrandomly in three different regions of the Tetrahymena genome. Nucleosome repeat length varied between adjacent nucleosomes. Nucleosome positioning in a histone H1 knockout strain was indistinguishable from that in a strain with wild type histone H1.
摘要
通过间接末端标记分析了嗜热四膜虫这种纤毛原生动物的体细胞大核基因组中的核小体定位。核小体在四膜虫基因组的三个不同区域呈非随机定位。相邻核小体之间的核小体重复长度有所不同。组蛋白H1敲除菌株中的核小体定位与野生型组蛋白H1菌株中的核小体定位没有区别。
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