Egyházi E
Proc Natl Acad Sci U S A. 1975 Mar;72(3):947-50. doi: 10.1073/pnas.72.3.947.
The nucleoside analogue 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, a selective inhibitor of heterogeneous chromosomal RNA synthesis in salivary gland cells of the midge Chironomus tentans, blocks the initiation of transcription in Balbiani rings 1 and 2. The analogue seems to be without appreciable effect on the elongation of growing RNA chains and allows finished molecules to be detached from the chromosomal sites. The RNA chain growth rate, based on measurements of the time required for completion of synthesis of Balbiani ring 1 and 2 RNA molecules after addition of the inhibitor, was estimated to be around 25 nucleotides per second at 18 degrees.
核苷类似物5,6-二氯-1-β-D-呋喃核糖基苯并咪唑是摇蚊Chironomus tentans唾液腺细胞中异源染色体RNA合成的选择性抑制剂，它能阻断巴尔比亚尼环1和2中的转录起始。该类似物似乎对正在生长的RNA链的延伸没有明显影响，并能使完成的分子从染色体位点上脱离。根据添加抑制剂后完成巴尔比亚尼环1和2 RNA分子合成所需时间的测量，RNA链的生长速率在18摄氏度时估计约为每秒25个核苷酸。
