关节腔内注射乳酸脱氢酶诱导的颞下颌关节骨关节炎：成年兔的实验研究
Osteoarthrosis of the temporomandibular joint induced by intra-articular injection of lactate dehydrogenase: an experimental study in adult rabbits.
作者信息
Tian H, Zhang Z G, He Y Q, Chen X R
机构信息
Guanghua Stomatology Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, P. R. China.
出版信息
Chin J Dent Res. 1998 Sep;1(2):62-7.
OBJECTIVE
The purpose of this study was to establish an animal model of osteoarthrosis in the temporomandibular joint (TMJOA) by injecting lactate dehydrogenase (LDH) into the maxillary compartments of TMJs in adult rabbits.
METHODS
Adult New Zealand white rabbits were randomly divided into four groups (A through D) of five animals each. The A and B groups were used as a control. The maxillary compartments of the C and D group (TMJs) were injected with 0.1 mL of LDH in two different concentrations. The TMJ samples were analyzed histologically and with a scanning electron microscope four different times after injection.
RESULTS
The animals that had been injected with LDH at two different concentrations showed similar results. The TMJs had changes typical of OA in early to moderate stages. No pathologic changes could be found in the TMJs of the control groups.
CONCLUSIONS
The results suggest that LDH may be of use in establishing an animal model of TMJOA.
目的
本研究的目的是通过向成年兔颞下颌关节（TMJ）的上颌腔注射乳酸脱氢酶（LDH）来建立颞下颌关节骨关节炎（TMJOA）的动物模型。
方法
成年新西兰白兔被随机分为四组（A至D），每组五只动物。A组和B组用作对照。C组和D组（TMJ）的上颌腔分别注射两种不同浓度的0.1 mL LDH。注射后在四个不同时间对TMJ样本进行组织学分析和扫描电子显微镜检查。
结果
注射两种不同浓度LDH的动物显示出相似的结果。TMJ呈现出早期至中期OA的典型变化。对照组的TMJ未发现病理变化。
结论
结果表明LDH可能有助于建立TMJOA的动物模型。
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