Synthesis and anti-Helicobacter pylori activity of FR182024, a new cephem derivative.
作者信息
Yoshida Y, Matsuda K, Sasaki H, Matsumoto Y, Matsumoto S, Takasugi H
机构信息
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
出版信息
Bioorg Med Chem Lett. 1999 Nov 1;9(21):3123-6. doi: 10.1016/s0960-894x(99)00549-1.
Abstract
The synthesis and anti-Helicobacter pylori activity of a novel cephem derivative FR182024 (1) are described. FR182024 having a (5-methyl-1,3,4-thiadiazol-2-yl)-thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have extremely potent in vitro anti-H.pylori activity, superior therapeutic efficacy to AMPC and CAM, and low potential for causing diarrhea.
摘要
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