Sepúlveda M A, Moreu J, Cantón T, Pajin F, Rodríguez L
Servicio de Cardiología, Hospital Virgen de la Salud, Toledo.
Enferm Infecc Microbiol Clin. 1999 Oct;17(8):386-9.
Over the past 25 years the potential role of herpesvirus and particularly Cytomegalovirus as a factor which contribute to atherogenesis, and more recently in restenosis, has been investigated.
To determine the rate of Cytomegalovirus seropositivity in patients with angiographically demonstrated Coronary Artery Atherosclerosis.
The subjects were all adult patients undergoing coronary angiography at the Hospital Virgen de la Salud, Toledo between February, 1997 and May, 1998. From each patient, blood was drawn and collected to be assayed. Also we collected the data from sex, age, classic risk factors for coronary artery disease (hypertension, hypercholesterolemia, diabetes and cigarette smoking) and catheterization. Data from 437 patients who underwent cardiac catheterization were collected. There was 349 (82.3%) patients who underwent catheterization because of Ischemic Heart Disease. SEROLOGIC ASSAYS: Serum IgG antibodies to cytomegalovirus were measured quantitatively with EIA, VIDAS, (bioMérieux). As recommended by the manufacturer a titer over 6 was considered positive.
There was 115 female and 319 males. Patients were 24-86 years old. Data from catheterization showed that 113 patients (26%) have no lesions on coronaryography and 321 patients (74%) have Coronary Artery Disease (CAD). The rate of Cytomegalovirus-seropositive was 97.1% in patients with lesions and 98.2% in those without lesions.
There is a high rate of antibodies positive for Cytomegalovirus in the population, in patients with Ischemic Heart Disease and with coronary artery disease as in those without lesions in the coronarigraphy. Our conclusion is that if Cytomegalovirus could have any role in the building of proliferating ateheromas and in view of seroepidemiological studies some other factors must be implicated in the development of plaque growth.
在过去25年里，人们一直在研究疱疹病毒尤其是巨细胞病毒在动脉粥样硬化形成过程中以及最近在再狭窄过程中所起的潜在作用。
确定经血管造影证实患有冠状动脉粥样硬化的患者中巨细胞病毒血清阳性率。
研究对象为1997年2月至1998年5月期间在托莱多市圣母健康医院接受冠状动脉造影的所有成年患者。从每位患者身上抽取血液并收集用于检测。我们还收集了患者的性别、年龄、冠状动脉疾病的经典危险因素（高血压、高胆固醇血症、糖尿病和吸烟）以及导管插入术的数据。收集了437例接受心脏导管插入术患者的数据。其中349例（82.3%）患者因缺血性心脏病接受导管插入术。血清学检测：采用酶免疫分析（EIA）、VIDAS（生物梅里埃公司）定量检测血清中抗巨细胞病毒IgG抗体。按照制造商的建议，滴度超过6被视为阳性。
患者中有115名女性和319名男性。患者年龄在24至86岁之间。导管插入术数据显示，113例患者（26%）冠状动脉造影无病变，321例患者（74%）患有冠状动脉疾病（CAD）。有病变患者的巨细胞病毒血清阳性率为97.1%，无病变患者的阳性率为98.2%。
在人群中，无论是缺血性心脏病患者、冠状动脉疾病患者还是冠状动脉造影无病变的患者，巨细胞病毒抗体阳性率都很高。我们的结论是，如果巨细胞病毒在增殖性动脉粥样硬化的形成中起任何作用，鉴于血清流行病学研究，斑块生长的发展肯定涉及其他一些因素。
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