编码人类突触结合蛋白IIa和IIb的cDNA的克隆

Cloning of cDNAs encoding human synapsins IIa and IIb.

作者信息

Porton B, Kao H T, Greengard P

机构信息

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA.

出版信息

DNA Seq. 1999;10(1):49-54. doi: 10.3109/10425179909033936.

DOI:10.3109/10425179909033936

PMID:10565545

Abstract

The synapsins are a family of neuronal phosphoproteins that are specifically associated with the cytoplasmic surface of synaptic vesicles. In mammals, distinct genes for synapsins I, II, and III give rise to members of the synapsin family. The synapsins are implicated in neurotransmitter release and synaptogenesis, processes believed to be aberrant in several neuropsychiatric diseases. The characterization of human synapsins is therefore important for evaluating the possible role of synapsins in human neuropathology. In this report, we describe the cloning and sequence of human synapsins IIa and IIb, products of the synapsin II gene. Human synapsins IIa and IIb conform to the previously described domain model of the synapsins, and the most conserved protein domains are A, C, and E.

摘要

突触结合蛋白是一类神经元磷蛋白，它们与突触小泡的胞质表面特异性相关。在哺乳动物中，突触结合蛋白I、II和III的不同基因产生了突触结合蛋白家族的成员。突触结合蛋白与神经递质释放和突触形成有关，而这些过程在几种神经精神疾病中被认为是异常的。因此，人类突触结合蛋白的特性对于评估突触结合蛋白在人类神经病理学中的可能作用很重要。在本报告中，我们描述了人类突触结合蛋白IIa和IIb（突触结合蛋白II基因的产物）的克隆和序列。人类突触结合蛋白IIa和IIb符合先前描述的突触结合蛋白结构域模型，最保守的蛋白结构域是A、C和E。