[胎儿肺成熟度评估在妊娠糖尿病中的价值]
[Value of fetal lung maturity assessment in maternal diabetes].
作者信息
Beinlich A, Fischäss C, Kaufmann M, Schlösser R, Dericks-Tan J S
机构信息
Frauenklinik, J. W. Goethe Universität, Frankfurt am Main.
出版信息
Zentralbl Gynakol. 1999;121(10):484-7.
OBJECTIVE
Results of antepartal fetal lung maturity (FLM) testing in diabetics were compared to control patients. We analysed 274 patients by phospholipid profile and 219 by phosphatidylglycerol (PG), consisting of 73, respectively 54 diabetic and 201, resp. 165 normal control subjects.
MATERIAL AND METHODS
Phospholipid concentration increased exponentially with gestational age (rreg = 0.44 for diabetic and 0.57 for normal control patients). There was no significant difference between both groups. Measurement of PG showed a trend towards lung immaturity in diabetic infants for preterm and term gestations, which did not reach significance (chi-square [chi 2] test 0.07, resp. 0.06).
RESULTS
Diabetic and non-diabetic pregnancies did not differ significantly in FLM and RDS frequency. Both methods show a high rate of falsely immature results. Antepartal FLM testing by measurement of phospholipids and PG does not play a role in clinical management of diabetic patients.
目的
将糖尿病患者产前胎儿肺成熟度（FLM）检测结果与对照患者进行比较。我们通过磷脂谱分析了274例患者，通过磷脂酰甘油（PG）分析了219例患者，其中分别有73例和54例为糖尿病患者，201例和165例为正常对照受试者。
材料与方法
磷脂浓度随孕周呈指数增加（糖尿病患者的rreg = 0.44，正常对照患者为0.57）。两组之间无显著差异。PG测量显示，早产和足月妊娠的糖尿病婴儿有肺不成熟的趋势，但未达到显著水平（卡方检验分别为0.07和0.06）。
结果
糖尿病和非糖尿病妊娠在FLM和呼吸窘迫综合征（RDS）发生率方面无显著差异。两种方法均显示出较高的假不成熟结果率。通过测量磷脂和PG进行产前FLM检测在糖尿病患者的临床管理中不起作用。
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