Wang Y, Gupta A, Markram H
Department of Neurobiology, The Weizmnann Institute for Science, Rehovot, Israel.
J Physiol Paris. 1999 Sep-Oct;93(4):305-17. doi: 10.1016/s0928-4257(00)80059-5.
Pyramidal neurons are the principal neurons of the neocortex and their excitatory impact on other pyramidal neurons and interneurons is central to neocortical dynamics. A fundamental principal that has emerged which governs pyramidal neuron excitation of other neurons in the local circuitry of neocortical columns is differential anatomical and physiological properties of the synaptic innervation via the same axon depending on the type of neuron targeted. In this study we derive anatomical principles for divergent innervation of pyramidal neurons of the same type within the local microcircuit. We also review data providing circumstantial and direct evidence for differential synaptic transmission via the same axon from neocortical pyramidal neurons and derive some principles for differential synaptic innervation of pyramidal neurons of the same type, of pyramidal neurons and interneurons and of different types of interneurons. We conclude that differential anatomical and physiological differentiation is a fundamental property of glutamatergic axons of pyramidal neurons in the neocortex.
锥体神经元是新皮层的主要神经元，它们对其他锥体神经元和中间神经元的兴奋性影响是新皮层动力学的核心。一个已出现的基本原理是，在新皮层柱的局部回路中，支配锥体神经元对其他神经元的兴奋作用的是，同一轴突根据所靶向神经元的类型而具有不同的解剖学和生理学特性的突触支配。在本研究中，我们推导了局部微回路中同一类型锥体神经元发散性支配的解剖学原理。我们还回顾了一些数据，这些数据为来自新皮层锥体神经元的同一轴突的差异性突触传递提供了间接和直接证据，并推导了同一类型锥体神经元、锥体神经元与中间神经元以及不同类型中间神经元的差异性突触支配的一些原理。我们得出结论，差异性解剖学和生理学分化是新皮层中锥体神经元谷氨酸能轴突的基本特性。
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