细胞骨架连接蛋白：旧靶点的新型微管相关蛋白

Cytoskeletal linkers: new MAPs for old destinations.

作者信息

Houseweart M K, Cleveland D W

机构信息

Program in Biomedical Sciences, Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, 92093, USA.

出版信息

Curr Biol. 1999 Nov 18;9(22):R864-6. doi: 10.1016/s0960-9822(00)80048-2.

DOI:10.1016/s0960-9822(00)80048-2

PMID:10574751

Abstract

A new isoform of the actin-neurofilament linker protein BPAG has been found that binds to and stabilizes axonal microtubules. This and other newly identified microtubule-associated proteins are likely to be just the tip of an iceberg of multifunctional proteins that stabilize and crosslink cytoskeletal filament networks.

摘要

已发现一种肌动蛋白-神经丝连接蛋白BPAG的新亚型，它能结合并稳定轴突微管。这种蛋白以及其他新鉴定出的微管相关蛋白可能只是稳定和交联细胞骨架丝网络的多功能蛋白的冰山一角。