Zhou W, Sørensen H T, Olsen J
Danish Epidemiology Science Centre, and the Department of Epidemiology and Social Medicine, Aarhus University, Denmark.
Obstet Gynecol. 1999 Dec;94(6):948-53. doi: 10.1016/s0029-7844(99)00440-8.
To examine whether induced abortion influences subsequent pregnancy duration.
Women who had their first pregnancies during 1980, 1981, and 1982 were identified in three Danish national registries. A total of 15,727 women whose pregnancies were terminated by first-trimester induced abortions were compared with 46,026 whose pregnancies were not terminated by induced abortions. All subsequent pregnancies until 1994 were identified by register linkage.
Preterm and post-term singleton live births were more frequent in women with one, two, or more previous induced abortions. After adjusting for potential confounders and stratifying by gravidity, the odds ratios of preterm singleton live births in women with one, two, or more previous induced abortions were 1.89 (95% confidence interval [CI] 1.70, 2.11), 2.66 (95% CI 2.09, 3.37), and 2.03 (95% CI 1.29, 3.19), respectively. Odds ratios of post-term singleton live births in women with one, two, or more previous induced abortions were 1.34 (95% CI 1.24, 1.44), 1.50 (95% CI 1.26, 1.78), and 1.58 (95% CI 1.09, 2.28), respectively.
The study showed an increase in preterm and post-term pregnancies after induced abortions. The risk of post-term delivery was high regardless of the interpregnancy interval, whereas increased risk of preterm delivery was seen mainly when interpregnancy intervals were longer than 12 months.
探讨人工流产是否会影响后续的妊娠时长。
在丹麦三个国家登记处识别出1980年、1981年和1982年首次怀孕的女性。共有15727例妊娠在孕早期通过人工流产终止的女性与46026例妊娠未通过人工流产终止的女性进行比较。通过登记链接识别出直至1994年的所有后续妊娠。
有过一次、两次或更多次既往人工流产史的女性中,早产和过期单胎活产更为常见。在对潜在混杂因素进行校正并按妊娠次数分层后,有过一次、两次或更多次既往人工流产史的女性发生早产单胎活产的比值比分别为1.89(95%置信区间[CI] 1.70,2.11)、2.66(95% CI 2.09,3.37)和2.03(95% CI 1.29,3.19)。有过一次、两次或更多次既往人工流产史的女性发生过期单胎活产的比值比分别为1.34(95% CI 1.24,1.44)、1.50(95% CI 1.26,1.78)和1.58(95% CI 1.09,2.28)。
该研究表明人工流产后早产和过期妊娠有所增加。无论妊娠间隔如何,过期分娩的风险都很高,而早产风险增加主要见于妊娠间隔超过12个月时。