Lo C W, Waldo K L, Kirby M L
Biology Department, University of Pennsylvania, Philadelphia 19104, USA.
Trends Cardiovasc Med. 1999 Apr-May;9(3-4):63-9. doi: 10.1016/s1050-1738(99)00015-8.
The analyses of transgenic and knockout mice with perturbations in alpha 1 connexin (Cx43) function have revealed an important role for gap junctions in cardiac development. This likely involves the modulation of cardiac crest migration and function. Studies carried out with these mouse models suggest that clinically there may be a novel category of cardiac defects involving crest perturbations that do not include outflow septation defects, but rather involve more subtle defects in the pulmonary outflow tract.
对α1连接蛋白（Cx43）功能受到干扰的转基因和基因敲除小鼠的分析表明，缝隙连接在心脏发育中具有重要作用。这可能涉及对心脏嵴迁移和功能的调节。用这些小鼠模型进行的研究表明，临床上可能存在一类新的心脏缺陷，涉及嵴的扰动，这些缺陷不包括流出道分隔缺陷，而是涉及肺流出道中更细微的缺陷。
Zotero 插件