Plat J, Mensink R P
Maastricht University, Department of Human Biology, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Atherosclerosis. 2000 Jan;148(1):101-12. doi: 10.1016/s0021-9150(99)00261-0.
A pine wood based stanol ester mixture-composed of sitostanol (92%) and campestanol (8%) effectively lowers cholesterol absorption and consequently LDL-cholesterol concentrations. It has been postulated that the less absorbable plant sterols reduce cholesterol absorption more effectively. As sitostanol is absorbed less than campestanol, we decided to examine if a vegetable oil based stanol ester mixture with 68% sitostanol and 32% campestanol is less effective than the wood based stanol ester mixture. For this, 112 non-hypercholesterolemic men and women consumed for 4 weeks a rapeseed oil (LEAR) based margarine and shortening. For the next 8 weeks, 42 subjects continued with these products, while the other subjects received products with a vegetable oil (n=36) or a pine wood based stanol ester mixture (n=34). Consumption of 3.8 g vegetable oil based stanols (2.6 g sitostanol plus 1.2 g campestanol) lowered LDL cholesterol 14.6+/-8.0% (-0.37 mmol/l; vs. the control group; P<0.001; 95% CI for the difference, -0.22 to -0. 51 mmol/l). Four grams pine wood based stanols (3.7 g sitostanol plus 0.3 g campestanol) showed a comparable decrease of 12.8+/-11.2% (-0.34 mmol/l; P<0.001; 95% CI-0.18 to-0.51 mmol/l). Decreases in LDL cholesterol were not different between the two experimental groups (P=0.793), while apoE genotype did not have a major impact on this hypocholesterolemic response. Serum HDL cholesterol and triacylglycerol concentrations were not changed. The decreases in apo B in both experimental groups differed significantly (P<0.001) from changes in the control group. Coagulation and fibrinolytic parameters were not affected. We therefore conclude that vegetable oil and wood based stanol ester mixtures, with a different sitostanol/campestanol ratio, have similar LDL cholesterol lowering effects in a non-hypercholesterolemic population.
一种由谷甾烷醇（92%）和菜子甾烷醇（8%）组成的基于松木的甾烷醇酯混合物能有效降低胆固醇吸收，进而降低低密度脂蛋白胆固醇浓度。据推测，吸收性较差的植物甾醇能更有效地降低胆固醇吸收。由于谷甾烷醇的吸收率低于菜子甾烷醇，我们决定研究一种含68%谷甾烷醇和32%菜子甾烷醇的基于植物油的甾烷醇酯混合物是否比基于松木的甾烷醇酯混合物效果差。为此，112名非高胆固醇血症的男性和女性连续4周食用以菜籽油（LEAR）为基础的人造黄油和起酥油。在接下来的8周里，42名受试者继续食用这些产品，而其他受试者分别食用含植物油的产品（n = 36）或基于松木的甾烷醇酯混合物的产品（n = 34）。食用3.8克基于植物油的甾烷醇（2.6克谷甾烷醇加1.2克菜子甾烷醇）可使低密度脂蛋白胆固醇降低14.6±8.0%（-0.37毫摩尔/升；与对照组相比；P<0.001；差异的95%置信区间为-0.22至-0.51毫摩尔/升）。4克基于松木的甾烷醇（3.7克谷甾烷醇加0.3克菜子甾烷醇）显示出类似的降低效果，降低了12.8±11.2%（-0.34毫摩尔/升；P<0.001；95%置信区间为-0.18至-0.51毫摩尔/升）。两个实验组的低密度脂蛋白胆固醇降低幅度没有差异（P = 0.793），而载脂蛋白E基因型对这种降胆固醇反应没有重大影响。血清高密度脂蛋白胆固醇和三酰甘油浓度没有变化。两个实验组中载脂蛋白B的降低与对照组的变化有显著差异（P<0.001）。凝血和纤溶参数未受影响。因此，我们得出结论，含不同谷甾烷醇/菜子甾烷醇比例的基于植物油和松木的甾烷醇酯混合物在非高胆固醇血症人群中具有相似的降低低密度脂蛋白胆固醇的效果。
