Borst P, Evers R, Kool M, Wijnholds J
Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
Biochim Biophys Acta. 1999 Dec 6;1461(2):347-57. doi: 10.1016/s0005-2736(99)00167-4.
The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family.
人类多药耐药蛋白（MRP）家族至少包含六个成员：家族中的“教父”MRP1，即众所周知的多药耐药蛋白，以及五个同源物，分别称为MRP2 - 6。在本综述中，我们总结了关于MRP家族各个成员的蛋白质结构、组织表达、细胞内转运、生理功能、底物特异性以及在多药耐药中的作用等方面的已知信息。
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