Ferranti V, Marchais H, Chabenat C, Orecchioni A M, Lafont O
Laboratoire de Pharmacochimie, U.F.R de Médecine-Pharmacie, 22 Boulevard Gambetta, 76183, Rouen Cedex, France.
Int J Pharm. 1999 Dec 20;193(1):107-11. doi: 10.1016/s0378-5173(99)00325-7.
This paper describes the preparation of primidone-loaded poly-epsilon-caprolactone nanocapsules according to the interfacial deposition technique. The colloidal suspension obtained showed a monomodal size distribution with a mean diameter ranging from 308 to 352 nm. By adjusting the process parameters, the encapsulation efficiency was about 74% with good reproducibility. Primidone release from the nanocapsules was found to be slower as compared to the oily control solution despite an important burst-effect. The release profile was not influenced by the pH of the release medium.
本文描述了根据界面沉积技术制备的扑米酮负载聚己内酯纳米胶囊。所获得的胶体悬浮液呈现单峰尺寸分布,平均直径在308至352纳米之间。通过调整工艺参数,包封率约为74%,重现性良好。尽管存在重要的突释效应,但发现扑米酮从纳米胶囊中的释放比油性对照溶液慢。释放曲线不受释放介质pH值的影响。