负载扑米酮的聚己内酯纳米胶囊：包封率及体外释放曲线

Primidone-loaded poly-epsilon-caprolactone nanocapsules: incorporation efficiency and in vitro release profiles.

作者信息

Ferranti V, Marchais H, Chabenat C, Orecchioni A M, Lafont O

机构信息

Laboratoire de Pharmacochimie, U.F.R de Médecine-Pharmacie, 22 Boulevard Gambetta, 76183, Rouen Cedex, France.

出版信息

Int J Pharm. 1999 Dec 20;193(1):107-11. doi: 10.1016/s0378-5173(99)00325-7.

DOI:10.1016/s0378-5173(99)00325-7

PMID:10581427

Abstract

This paper describes the preparation of primidone-loaded poly-epsilon-caprolactone nanocapsules according to the interfacial deposition technique. The colloidal suspension obtained showed a monomodal size distribution with a mean diameter ranging from 308 to 352 nm. By adjusting the process parameters, the encapsulation efficiency was about 74% with good reproducibility. Primidone release from the nanocapsules was found to be slower as compared to the oily control solution despite an important burst-effect. The release profile was not influenced by the pH of the release medium.

摘要

本文描述了根据界面沉积技术制备的扑米酮负载聚己内酯纳米胶囊。所获得的胶体悬浮液呈现单峰尺寸分布，平均直径在308至352纳米之间。通过调整工艺参数，包封率约为74%，重现性良好。尽管存在重要的突释效应，但发现扑米酮从纳米胶囊中的释放比油性对照溶液慢。释放曲线不受释放介质pH值的影响。