Bruntsch U, Osieka R, GAllmeier W M, Seeber S, Schmidt C G
Dtsch Med Wochenschr. 1975 Nov 28;100(48):2478-82. doi: 10.1055/s-0028-1106569.
In 21 patients with acute leukaemia not or no longer responsive to conventional chemotherapy, and in four patients with chronic myeloid leukaemia in the blast phase, intensive combination treatment was started with thioguanine, daunomycine, cytarabine, methotrexate, prednisone, cyclophosphamide, and vincristine. Six patients with acute leukaemia went into complete remission, three into partial remission. The mean duration of remission was relatively short at 11 weeks. Of the four patients in the blast phase of chronic myeloid leukaemia two had objective and subjective remission. The toxicity of the combined treatment was not marked and subjective tolerance good. Such combined treatment is a realistic means of managing treatment-resistant acute leukaemia and chronic myeloid leukaemia in the blast phase.
在21例对传统化疗无反应或不再有反应的急性白血病患者以及4例处于急变期的慢性粒细胞白血病患者中，开始采用硫鸟嘌呤、柔红霉素、阿糖胞苷、甲氨蝶呤、泼尼松、环磷酰胺和长春新碱进行强化联合治疗。6例急性白血病患者达到完全缓解，3例达到部分缓解。缓解的平均持续时间相对较短，为11周。4例处于慢性粒细胞白血病急变期的患者中有2例出现客观和主观缓解。联合治疗的毒性不明显，主观耐受性良好。这种联合治疗是治疗难治性急性白血病和处于急变期的慢性粒细胞白血病的一种切实可行的方法。
