钱迪普拉病毒的基质蛋白抑制RNA聚合酶II启动子的转录。

Matrix protein of Chandipura virus inhibits transcription from an RNA polymerase II promoter.

作者信息

Taylor A, Easton A J, Marriott A C

机构信息

Department of Biological Sciences, University of Warwick, Coventry, UK.

出版信息

Virus Genes. 1999;19(3):223-8. doi: 10.1023/a:1008188730975.

DOI:10.1023/a:1008188730975

PMID:10595413

Abstract

Chandipura virus (CHPV) is a Vesiculovirus, related to, but phylogenetically distinct from, vesicular stomatitis virus (VSV). The matrix protein of VSV, as well as its role in virus assembly, inhibits the transcription from promoters for host RNA polymerases I and II. Cloning and expression of the matrix protein of CHPV in human cells showed that this protein is also functional in its inhibitory effect on transcription of a reporter gene from the cytomegalovirus immediate-early promoter, despite sharing only 28% amino acid sequence identity with the matrix protein of VSV.

摘要

钱迪普拉病毒（CHPV）是一种水疱病毒，与水疱性口炎病毒（VSV）相关，但在系统发育上有所不同。VSV的基质蛋白及其在病毒组装中的作用，会抑制宿主RNA聚合酶I和II启动子的转录。在人类细胞中克隆和表达CHPV的基质蛋白表明，尽管该蛋白与VSV的基质蛋白仅共享28%的氨基酸序列同一性，但它对来自巨细胞病毒立即早期启动子的报告基因转录也具有抑制作用。