Friedman P A, Bushinsky D A
Department of Pharmacology, University of Pittsburgh, PA, USA.
Semin Nephrol. 1999 Nov;19(6):551-6.
Diuretics have numerous effects on calcium metabolism. The loop diuretics promote, and the thiazide diuretics inhibit, renal calcium excretion. In this review we detail the basic mechanisms of renal calcium excretion and then explain how diuretics influence this excretion. Finally we review how these agents can be used to alter calcium homeostasis in a clinically efficacious manner.
利尿剂对钙代谢有多种影响。袢利尿剂促进肾钙排泄,而噻嗪类利尿剂抑制肾钙排泄。在本综述中,我们详细阐述肾钙排泄的基本机制,然后解释利尿剂如何影响这种排泄。最后,我们回顾这些药物如何以临床有效的方式用于改变钙稳态。