Quigley H A, Varma R, Tielsch J M, Katz J, Sommer A, Gilbert D L
Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
J Glaucoma. 1999 Dec;8(6):347-52.
To determine if eyes with larger optic disc area are more likely to have open-angle glaucoma or to have glaucoma at lower intraocular pressure (IOP).
Data were collected from a population-based sample of adults residing in East Baltimore, consisting of demographic information, ocular examinations, automated and static/kinetic visual field tests, IOP as measured by applanation tonometry, and image analysis of the optic disc. Optic disc area was calculated using refractive error to correct magnification. Open-angle glaucoma was defined by visual field and optic disc criteria. One eye from each of 75 patients with glaucoma was compared to those of 3,518 subjects without glaucoma.
Although optic disc area was somewhat larger among patients with glaucoma than control subjects, in a regression model adjusting for age, gender, and race, the significance of this difference had a probability of 0.06. Among patients with glaucoma, disc area was not related to IOP level measured at study examination.
Disc area is a weak risk factor for open-angle glaucoma. Disc area did not differ between patients with glaucoma who had lower IOP and those who had higher IOP among a group with glaucoma that were identified in a population survey.
确定视盘面积较大的眼睛是否更易患开角型青光眼，或在较低眼压时患青光眼。
从居住在东巴尔的摩的成年人的人群样本中收集数据，包括人口统计学信息、眼部检查、自动及静态/动态视野测试、压平眼压计测量的眼压，以及视盘的图像分析。使用屈光不正校正放大率来计算视盘面积。开角型青光眼由视野和视盘标准定义。将75例青光眼患者的一只眼睛与3518例无青光眼受试者的眼睛进行比较。
尽管青光眼患者的视盘面积比对照组略大，但在调整年龄、性别和种族的回归模型中，这种差异的显著性概率为0.06。在青光眼患者中，视盘面积与研究检查时测量的眼压水平无关。
视盘面积是开角型青光眼的一个弱风险因素。在一项人群调查中确定的一组青光眼患者中，眼压较低的青光眼患者与眼压较高的青光眼患者之间的视盘面积没有差异。
