1型人类免疫缺陷病毒糖蛋白120疫苗接种后突破性感染受试者的抗体和细胞免疫反应

Antibody and cellular immune responses in breakthrough infection subjects after HIV type 1 glycoprotein 120 vaccination.

作者信息

Locher C P, Grant R M, Collisson E A, Reyes-Terán G, Elbeik T, Kahn J O, Levy J A

机构信息

Department of Medicine, University of California, San Francisco 94143, USA.

出版信息

AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1685-9. doi: 10.1089/088922299309720.

DOI:10.1089/088922299309720

PMID:10606091

Abstract

HIV-specific antibodies and CD8+ T cell antiviral responses were evaluated in three human immunodeficiency virus 1 (HIV-1) gp120 vaccine recipients who later became infected with HIV-1. Titers of neutralizing antibody to the HIV-1(SF2) vaccine isolate were boosted, but titers of antibody to the autologous infecting viruses were never high and required at least 6 months after HIV infection to develop. Similarly, a marginal noncytotoxic CD8+ T cell antiviral response was observed only in one of the three vaccinees 3 months after HIV-1 infection. The infecting virus isolates had several amino acid substitutions in the HIV-1 envelope V3 region but were similar to other regional HIV-1 clade B isolates. Viral loads were similar to those of other HIV-1-infected individuals who had not been vaccinated and transient CD4+ T cell declines were observed in each person, suggesting that the vaccine was not effective at controlling these prognostic markers early in infection.

摘要

在三名后来感染了人类免疫缺陷病毒1型（HIV-1）的HIV-1 gp120疫苗接种者中评估了HIV特异性抗体和CD8 + T细胞抗病毒反应。针对HIV-1（SF2）疫苗毒株的中和抗体滴度有所提高，但针对自体感染病毒的抗体滴度一直不高，且在HIV感染后至少需要6个月才会产生。同样，在HIV-1感染3个月后，仅在三名接种者中的一名中观察到了微弱的非细胞毒性CD8 + T细胞抗病毒反应。感染的病毒毒株在HIV-1包膜V3区域有几个氨基酸替换，但与其他区域性HIV-1 B亚型毒株相似。病毒载量与未接种疫苗的其他HIV-1感染者相似，并且在每个人中都观察到了短暂的CD4 + T细胞下降，这表明该疫苗在感染早期对控制这些预后指标无效。