Synthesis of inositol phosphates and phospholipids.

Inositol phospholipids and their hydrolysis products have been recognized to play important roles in an intracellular signal transduction system. Since their contents in cells are quite low, synthetic methods for their production are required. Chemical synthesis of various inositol phosphates and inositol phospholipids, including natural phosphatidylinositol 3,4,5-trisphosphate, have been efficiently accomplished. For this purpose, several new reactions and reagents were developed.