Komp D M, George S L, Falletta J, Land V J, Starling K A, Humphrey G B, Lowman J
Cancer. 1976 Mar;37(3):1243-7. doi: 10.1002/1097-0142(197603)37:3<1243::aid-cncr2820370303>3.0.co;2-6.
A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction. The more intensive regimen was associated with a lower complete remission rate (81% vs 93%) and a higher early death rate from infection (15% vs 5%) for acute lymphocytic leukemia. In contrast, complete remission was achieved in 58% of children with acute nonlymphocytic leukemia treated with CAVP compared to 18% for VP. Early death rates were similar (27% vs 25%). These observations corroborate previous studies in childhood nonlymphocytic leukemia showing activity for asparaginase. Preliminary analysis of remission duration and survival for responders shows no advantage for those who survived the more intensive induction.
将使用环磷酰胺、天冬酰胺酶、长春新碱和泼尼松（CAVP）的儿童白血病缓解诱导方案与标准长春新碱-泼尼松（VP）诱导方案进行了比较。对于急性淋巴细胞白血病，更强化的方案与较低的完全缓解率（81%对93%）和较高的感染早期死亡率（15%对5%）相关。相比之下，接受CAVP治疗的急性非淋巴细胞白血病儿童中58%实现了完全缓解，而接受VP治疗的为18%。早期死亡率相似（27%对25%）。这些观察结果证实了先前关于儿童非淋巴细胞白血病中天冬酰胺酶活性的研究。对缓解期和缓解者生存率的初步分析表明，对于在更强化诱导中存活下来的患者没有优势。
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