Pandeya S N, Ponnilavarasan I, Pandey A, Lakhan R, Stables J P
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Pharmazie. 1999 Dec;54(12):923-5.
A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors.
合成了一系列对硝基苯基取代的氨基脲，并针对最大电休克发作（MES）、皮下注射戊四氮（scPTZ）和皮下注射士的宁（scSTY）对它们的抗惊厥活性进行了筛选。已发现4-(4'-硝基苯基)-邻硝基苯甲醛氨基脲在所有这些测试中活性最高。研究表明，在该系列氨基脲类化合物中，伯氨基官能团对于抗惊厥活性并非必不可少。据推测，这些化合物可能进一步作用于甘氨酸受体。
Zotero 插件