Wang R F, Podos S M, Serle J B, Mittag T W, Ventosa F, Becker B
Department of Ophthalmology, Mount Sinai School of Medicine of New York University, New York, USA.
Arch Ophthalmol. 2000 Jan;118(1):74-7. doi: 10.1001/archopht.118.1.74.
To evaluate the possible additivity of the effects of latanoprost and 8-iso prostaglandin E2 (8-iso PGE2) on intraocular pressure (IOP) in monkey eyes with laser-induced glaucoma.
The IOP was measured hourly for 6 hours beginning at 9:30 AM on day 1 (baseline day), days 6 and 7 (single-agent therapy), and days 13 and 14 (combination therapy with both agents). Following 1 day of baseline measurement, 4 monkeys with unilateral glaucoma received monotherapy) twice daily with either 1 drop of 0.005% latanoprost, or 0.1% 8-iso PGE2, 25 microL, at 9:30 AM and 3:30 PM from days 2 through 7. From days 8 through 14, both agents were applied twice daily 5 minutes apart.
The maximum reduction of IOP (mean +/- SEM) was 8.8 +/- 1.9 mmHg (26%) (P<.05) with latanoprost alone and 6.5 +/- 1.0 mmHg (21%) (P<.0l) with 8-iso PGE2 alone, 2 hours after the morning dosing on day 7. A further reduction of IOP of 4.0 +/- 0.6 mm Hg was produced when 8-iso PGE2 was added to latanoprost and of 3.0 +/- 0.7 mm Hg was produced when latanoprost was added to 8-iso PGE2 on day 13 before the morning dosing. Combination therapy with both agents caused maximum IOP reductions from baseline of 11.3 +/- 3.0 mm Hg (33%) (P<.05) (latanoprost with 8-iso PGE2 added) and of 9.8 +/- 1.3 mm Hg (31%) (P<.01) (8-iso PGE2 with latanoprost added) on day 14.
Latanoprost and 8-iso PGE2 have an additive effect on IOP in glaucomatous monkey eyes.
At least 50% of patients are treated with more than 1 ocular hypotensive medication. Thus, the determination of the additive effects on IOP of glaucoma medications will help to define optimum treatment regimens.
评估拉坦前列素和8-异前列腺素E2（8-异PGE2）对激光诱导性青光眼猴眼眼压（IOP）的可能相加作用。
在第1天（基线日）、第6天和第7天（单药治疗）以及第13天和第14天（两种药物联合治疗），从上午9:30开始每小时测量一次眼压，持续6小时。在进行1天的基线测量后，4只单侧青光眼猴子从第2天至第7天每天上午9:30和下午3:30接受单药治疗，每天两次，每次1滴0.005%拉坦前列素或0.1% 8-异PGE2，25微升。从第8天至第14天，两种药物每天两次间隔5分钟应用。
在第7天上午给药后2小时，单独使用拉坦前列素时眼压最大降幅（均值±标准误）为8.8±1.9 mmHg（26%）（P<0.05），单独使用8-异PGE2时为6.5±1.0 mmHg（21%）（P<0.01）。在第13天上午给药前，当8-异PGE2添加到拉坦前列素中时眼压进一步降低4.0±0.6 mmHg，当拉坦前列素添加到8-异PGE2中时眼压进一步降低3.0±0.7 mmHg。两种药物联合治疗在第14天导致眼压从基线最大降幅为11.3±3.0 mmHg（33%）（P<0.05）（添加8-异PGE2的拉坦前列素）和9.8±1.3 mmHg（31%）（P<0.01）（添加拉坦前列素的8-异PGE2）。
拉坦前列素和8-异PGE2对青光眼猴眼的眼压有相加作用。
至少50%的患者接受一种以上的降眼压药物治疗。因此，确定青光眼药物对眼压的相加作用将有助于确定最佳治疗方案。
