足月妊娠时的血小板计数：阈值的重新评估。

Platelet count at term pregnancy: a reappraisal of the threshold.

作者信息

Boehlen F, Hohlfeld P, Extermann P, Perneger T V, de Moerloose P

机构信息

Department of Internal Medicine, University Hospital, Geneva, Switzerland.

出版信息

Obstet Gynecol. 2000 Jan;95(1):29-33. doi: 10.1016/s0029-7844(99)00537-2.

DOI:10.1016/s0029-7844(99)00537-2

PMID:10636497

Abstract

OBJECTIVE

To assess the safety of a new platelet count threshold for the definition of maternal thrombocytopenia late in pregnancy.

METHODS

A platelet count was performed in 6770 pregnant women late in pregnancy and in 6103 of their newborns as well as in a control group of 287 age-matched nonpregnant healthy women.

RESULTS

The prevalence of maternal thrombocytopenia (platelet count less than 150 x 10(9)/L) was 11.6%. The mean platelet counts (248 compared with 213 x 10(9)/L) and 2.5th percentile (164 compared with 116 x 10(9)/L) were significantly higher in healthy nonpregnant women than in pregnant women. Among thrombocytopenic pregnant women, 621 (79%) had platelet counts between 116 and 149 x 10(9)/L; none (0%; 95% confidence interval 0, 0.6) had complications related to thrombocytopenia, and none of their newborns had severe thrombocytopenia (platelet count less than 20 x 10(9)/L).

CONCLUSION

In healthy pregnant women, a platelet count over 115 x 10(9)/L late in pregnancy does not require further investigation during pregnancy and may be considered a safe threshold.

摘要

目的

评估用于定义妊娠晚期孕妇血小板减少症的新血小板计数阈值的安全性。

方法

对6770名妊娠晚期孕妇及其6103名新生儿进行血小板计数，并对287名年龄匹配的非妊娠健康女性组成的对照组进行血小板计数。

结果

孕妇血小板减少症（血小板计数低于150×10⁹/L）的患病率为11.6%。健康非妊娠女性的平均血小板计数（分别为248与213×10⁹/L）和第2.5百分位数（分别为164与116×10⁹/L）显著高于孕妇。在血小板减少的孕妇中，621名（79%）的血小板计数在116至149×10⁹/L之间；无一例（0%；95%置信区间0，0.6）出现与血小板减少相关的并发症，且她们的新生儿均无严重血小板减少症（血小板计数低于20×10⁹/L）。