细胞内铜离子的转运：铜伴侣蛋白的作用。

Intracellular copper routing: the role of copper chaperones.

作者信息

Harrison M D, Jones C E, Solioz M, Dameron C T

机构信息

Department of Biochemistry and Genetics, The Medical School, University of Newcastle, UK NE2 4HH.

出版信息

Trends Biochem Sci. 2000 Jan;25(1):29-32. doi: 10.1016/s0968-0004(99)01492-9.

DOI:10.1016/s0968-0004(99)01492-9

PMID:10637610

Abstract

Copper is required by all living systems. Cells have a variety of mechanisms to deal with this essential, yet toxic trace element. A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the 'copper chaperones'. They are a family of conserved proteins present in prokaryotes and eukaryotes, which suggests that copper chaperones are used throughout nature for intracellular copper routing.

摘要

所有生物系统都需要铜。细胞有多种机制来应对这种必需但又有毒的微量元素。稳态机制最近发现的一个方面是蛋白质介导的铜在细胞内传递至靶蛋白。这种传递是由一类新型蛋白质“铜伴侣蛋白”完成的。它们是存在于原核生物和真核生物中的一组保守蛋白质，这表明铜伴侣蛋白在自然界中被用于细胞内的铜传递。