接受“马利兰”治疗患者的染色体变化。
Chromosome changes in patients treated with "Myleran".
作者信息
Krajincanić B, Lazarov A, Zunić Z, Radojicić B
出版信息
Strahlentherapie. 1976 May;151(5):459-62.
The aim of this study is the determination of chromosomal changes in patients suffering from chronic leucosis, after therapy with the cytostatic "Myleran", to find out whether this cytostatic causes them, because of clinical experience which indicates its value in the treatment of chronic myeloid leukemia. Patients were treated with therapeutic doses of 4 mg per os daily. Analysis with present methods in patients receiving relatively small total doses did not discover the other visible chromosomal aberrations in leucocytes in peripheral blood, except the usual aberrations caused by chronic leucosis.
本研究的目的是确定慢性白血病患者在接受细胞抑制剂“马利兰”治疗后染色体的变化，以查明这种细胞抑制剂是否会导致染色体变化，这是基于临床经验表明其在慢性粒细胞白血病治疗中的价值。患者每天口服4毫克治疗剂量。采用现有方法对接受相对小总剂量治疗的患者进行分析，除了慢性白血病引起的常见畸变外，未发现外周血白细胞中有其他可见的染色体畸变。
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