Earn D J, Rohani P, Bolker B M, Grenfell B T
Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Science. 2000 Jan 28;287(5453):667-70. doi: 10.1126/science.287.5453.667.
Dramatic changes in patterns of epidemics have been observed throughout this century. For childhood infectious diseases such as measles, the major transitions are between regular cycles and irregular, possibly chaotic epidemics, and from regionally synchronized oscillations to complex, spatially incoherent epidemics. A simple model can explain both kinds of transitions as the consequences of changes in birth and vaccination rates. Measles is a natural ecological system that exhibits different dynamical transitions at different times and places, yet all of these transitions can be predicted as bifurcations of a single nonlinear model.
在整个本世纪,已观察到流行病模式的巨大变化。对于麻疹等儿童传染病而言,主要转变发生在规则周期与不规则(可能是混沌的)流行病之间,以及从区域同步振荡到复杂的、空间上非相干的流行病之间。一个简单的模型可以将这两种转变解释为出生率和疫苗接种率变化的结果。麻疹是一个自然生态系统,它在不同时间和地点呈现出不同的动态转变,但所有这些转变都可以作为单个非线性模型的分岔来预测。