Sayit E, Dirik E, Durak H, Uzuner N, Anal O, Cevik N T
Department of Nuclear Medicine, Celal Bayar University Faculty of Medicine, Manisa, Turkey.
Ann Nucl Med. 1999 Dec;13(6):415-8. doi: 10.1007/BF03164936.
Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia with seizures and electroencephalogram (EEG) abnormalities. Tc-99m-HMPAO SPECT was performed in three right handed children with LKS. A relative decrease in perfusion was found in the left temporal cortex of all three patients and also in the left frontoparietal cortex of one patient with hyperkinetic behavior. Degree of regional cerebral perfusion impairment did not correlate with the severity of clinical and EEG abnormalities. Asymmetrical temporoparietal perfusion appears characteristic of LKS. SPECT findings in LKS were evaluated as useful in elucidating the pathogenic features of the disorder in the brain.
Landau-Kleffner综合征（LKS）是一种罕见的儿童疾病，其特征为获得性失语伴癫痫发作和脑电图（EEG）异常。对三名右利手的LKS患儿进行了锝-99m-六甲基丙烯胺肟单光子发射计算机断层扫描（Tc-99m-HMPAO SPECT）。所有三名患者的左侧颞叶皮质均发现灌注相对减少，一名有多动行为的患者左侧额顶叶皮质也发现灌注相对减少。局部脑灌注损害程度与临床和脑电图异常的严重程度无关。颞顶叶不对称灌注似乎是LKS的特征。LKS的SPECT检查结果被认为有助于阐明该疾病在大脑中的致病特征。
