锶作为肠道钙吸收的标志物：骨化三醇的刺激作用。

Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol.

作者信息

Dijkgraaf-Ten Bolscher M, Netelenbos J C, Barto R, van Der Vijgh W J

机构信息

Department of Endocrinology and Clinical Research Laboratory of Internal Medicine, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

出版信息

Clin Chem. 2000 Feb;46(2):248-51.

PMID:10657381

Abstract

BACKGROUND

Intestinal strontium absorption is becoming accepted as a clinical and diagnostic tool for assessing intestinal calcium absorption in humans. However, little is known about whether intestinal strontium absorption, like that of calcium, is stimulated by calcitriol in healthy humans.

METHODS

The effect of calcitriol on intestinal strontium absorption was measured in eight healthy men, ages 20-60 years. Before administration of calcitriol, two tests were performed with an interval of 10 days for calculating the within-subject variation (SE(R)). Before the third test, 0.5 microg of calcitriol was given twice daily for 3 days. In each test, the fractional strontium absorption (Fc(240)) and the area under the concentration-time curve (AUC(0-240)) 4 h after an oral strontium load of 2.5 mmol were calculated.

RESULTS

The within-subject SE(R) of Fc(240) and AUC(0-240) was 1.7 +/- 0.7 and 0.83 +/- 0.1, respectively. The stimulatory effect of calcitriol on Fc(240) and AUC(0-240) was 35% (21.8 +/- 2.0 to 28.8 +/- 2.4; P = 0.003) and 61% (8.97 +/- 0.97 to 14.4 +/- 1.3 mmol. L(-1). min; P = 0.001), respectively.

CONCLUSIONS

Although the reproducibility of AUC(0-240) and its sensitivity to calcitriol were better than those of Fc(240), the Fc(240) of strontium is preferred for a clinical test because of its simplicity, requiring only two instead of five blood samples.

摘要

背景

肠道锶吸收正逐渐被认可为评估人体肠道钙吸收的一种临床及诊断工具。然而，对于在健康人群中，肠道锶吸收是否像钙吸收一样受骨化三醇刺激，人们了解甚少。

方法

对8名年龄在20至60岁的健康男性，测量骨化三醇对肠道锶吸收的影响。在给予骨化三醇之前，进行两次测试，间隔10天，以计算受试者内变异（SE(R)）。在第三次测试前，每天两次给予0.5微克骨化三醇，共3天。在每次测试中，计算口服2.5毫摩尔锶负荷后4小时的锶吸收分数（Fc(240)）和浓度-时间曲线下面积（AUC(0-240)）。

结果

Fc(240)和AUC(0-240)的受试者内SE(R)分别为1.7±0.7和0.83±0.1。骨化三醇对Fc(240)和AUC(0-240)的刺激作用分别为35%（从21.8±2.0至28.8±2.4；P = 0.003）和61%（从8.97±0.97至14.4±1. mmol·L(-1)·min；P = 0.001）。