含环丙沙星的可生物降解聚（d，l）乳酸-聚（l）乳酸复合微胶囊的药物缓释特性
Sustained drug release characteristics of biodegradable composite poly(d,l)lactic acid-poly(l)lactic acid microcapsules containing ciprofloxacin.
作者信息
Yu W P, Wong J P, Chang T M
机构信息
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
出版信息
Artif Cells Blood Substit Immobil Biotechnol. 2000 Jan;28(1):39-55. doi: 10.3109/10731190009119784.
Ciprofloxacin polylactic microcapsules were prepared by the phase separation process. Two types of polylactic acid, poly(d,l)lactic acid and poly(l)lactic acid were combined as membrane materials to prevent the aggregation which happened frequently in the phase separation process. The polymer compositions of the microcapsules can influence the release rate of Ciprofloxacin. The optimal release rate of the drug can be obtained by modifying microcapsule compositions. Poly(d,l)lactic acid is superior in slowing the rate of drug release than poly(l)lactic acid. However, poly(l)lactic acid is necessary in the preparation of the microcapsules to prevent aggregation.
采用相分离法制备了环丙沙星聚乳酸微胶囊。将两种聚乳酸，即聚（d，l）乳酸和聚（l）乳酸作为膜材料组合使用，以防止在相分离过程中频繁发生的聚集现象。微胶囊的聚合物组成会影响环丙沙星的释放速率。通过改变微胶囊组成可获得药物的最佳释放速率。聚（d，l）乳酸在减缓药物释放速率方面优于聚（l）乳酸。然而，在微胶囊制备过程中聚（l）乳酸对于防止聚集是必要的。
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