雷米普利对心肌梗死后心脏血管紧张素II受体基因转录水平的影响。
Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction.
作者信息
Zhu Y C, Zhu Y Z, Li J, Schäfer H, Schmidt W E, Unger T, Yao T
机构信息
Department of Physiology, Shanghai Medical University, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Jun;20(6):481-5.
AIM
To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril.
METHODS
MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium.
RESULTS
AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI.
CONCLUSION
The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition.
目的
研究长期接受血管紧张素转换酶（ACE）抑制剂雷米普利治疗的大鼠心肌梗死后心脏血管紧张素（Ang）II受体基因转录的早期变化。
方法
通过结扎大鼠左冠状动脉前降支诱导心肌梗死，假手术大鼠作为对照。在手术前1周开始，大鼠每日接受雷米普利（1mg·kg-1）或水治疗。应用定量逆转录聚合酶链反应（RT-PCR）测定非梗死心肌中Ang II受体AT1、AT2受体基因的mRNA水平。
结果
心肌梗死后，心脏间隔中AT1和AT2 mRNA水平随时间点依赖性增加，在第1天达到峰值。心肌梗死后，雷米普利治疗组和水治疗组大鼠心肌AT1和AT2受体mRNA水平无显著差异。
结论
非梗死心肌中AT1和AT2受体基因转录与心肌梗死后心脏重构过程有关，但不受ACE抑制的影响。
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