烯丙基硫胺二硫化物及相关化合物可通过增加大鼠去甲肾上腺素和肾上腺素的分泌来增强产热作用。

Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats.

作者信息

Oi Y, Shishido C, Wada K, Odaka H, Ikeda H, Iwai K

机构信息

Laboratory of Nutrition Chemistry, Faculty of Home Economics, Kobe Women's University, Japan.

出版信息

J Nutr Sci Vitaminol (Tokyo). 1999 Oct;45(5):643-53. doi: 10.3177/jnsv.45.643.

DOI:10.3177/jnsv.45.643

PMID:10683815

Abstract

The effects of allylthiamindisulfide, an allyl derivative of thiamin, and related compounds on thermogenesis were investigated by measuring noradrenaline and adrenaline secretion and the temperatures of interscapular brown adipose tissue (IBAT) and rectum in rats. In Experiment 1, the effects of the administrations of allylthiamindisulfide and related compounds on noradrenaline and adrenaline secretion were evaluated as compared to thiamin in anesthetized rats. The administration of allylthiamindisulfide significantly increased the plasma concentrations of noradrenaline and adrenaline. These increases were dose dependent, while that of thiamin was not. Four synthetic compounds related to allylthiamindisulfide also increased the plasma adrenaline and noradrenaline concentrations. In Experiment 2, the effects of allylthiamindisulfide on thermogenesis were investigated by the direct measurement of temperatures in the IBAT and rectum in anesthetized rats, and compared to the effects induced by thiamin and diallyldisulfide. The temperatures in the IBAT and rectum were significantly increased by the administration of allylthiamindisulfide and diallyldisulfide, while there was no significant increase as the result of thiamin administration. These results suggest that allylthiamindisulfide and related compounds enhance thermogenesis by increasing noradrenaline and adrenaline secretion in rats.

摘要

通过测量大鼠去甲肾上腺素和肾上腺素的分泌以及肩胛间棕色脂肪组织（IBAT）和直肠的温度，研究了硫胺素的烯丙基衍生物烯丙基硫胺二硫化物及相关化合物对产热的影响。在实验1中，将烯丙基硫胺二硫化物及相关化合物的给药对去甲肾上腺素和肾上腺素分泌的影响与硫胺素在麻醉大鼠中的作用进行了比较评估。烯丙基硫胺二硫化物的给药显著提高了去甲肾上腺素和肾上腺素的血浆浓度。这些升高呈剂量依赖性，而硫胺素则不然。与烯丙基硫胺二硫化物相关的四种合成化合物也提高了血浆肾上腺素和去甲肾上腺素的浓度。在实验2中，通过直接测量麻醉大鼠IBAT和直肠的温度来研究烯丙基硫胺二硫化物对产热的影响，并与硫胺素和二烯丙基二硫化物诱导的影响进行比较。烯丙基硫胺二硫化物和二烯丙基二硫化物的给药显著提高了IBAT和直肠的温度，而硫胺素给药则未导致显著升高。这些结果表明，烯丙基硫胺二硫化物及相关化合物通过增加大鼠去甲肾上腺素和肾上腺素的分泌来增强产热。