由N-未取代的偕胺肟合成4,5-二氢-1,2,4-恶二唑
[Synthesis of 4,5-dihydro-1,2,4-oxadiazoles from N-unsubstituted amidoximes].
作者信息
Lessel J, Herfs G
机构信息
Institut für Pharmazeutische Chemie, Heinrich-Heine-Universität Düsseldorf, Germany.
出版信息
Pharmazie. 2000 Jan;55(1):22-6.
PMID:10683866
Abstract
4,5-Dihydro 1,2,4-oxadiazoles can be synthesized from aromatic and araliphatic amidoximes by cyclocondensation with aldehydes and ketones. Resulting heterocycles differ in substitution at C-3 and C-5 showing the scope of the simple reaction.
摘要
4,5-二氢-1,2,4-恶二唑可通过芳族和芳脂族偕胺肟与醛和酮的环缩合反应合成。所得杂环在C-3和C-5处的取代情况不同，显示出该简单反应的适用范围。
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