Sundaramurthy D, Pieri L F, Gape H, Markham A F, Campbell D A
Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds, United Kingdom.
Am J Med Genet. 2000 Feb 7;96(1):53-5.
Previous studies have demonstrated aberrant expression of serotonin in individuals with an eating disorder. Given this the serotonin transporter gene (5-HTT) is a strong candidate to contribute to the genetic component of the aetiology of eating disorders. To determine the role of this particular gene in the susceptibility to anorexia nervosa (AN) we have examined a tandemly repeated sequence close to the promotor region of the 5-HTT gene, which is represented by a long (L) and short (S) variant. Previous studies have shown that the transcriptional activity of the 5-HTT gene differs significantly between these two alleles. A group of 138 Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria AN patients and 90 controls were genotyped at the 5-HTT gene linked polymorphism (5-HTTLPR). Statistical analysis showed no significant difference in allele or genotype frequencies between the two groups. These data suggest that there is no association between 5-HTTLPR genotype and susceptibility to AN, in our population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:53-55, 2000.
先前的研究表明，患有饮食失调症的个体中血清素表达异常。鉴于此，血清素转运体基因（5-HTT）很可能是导致饮食失调症病因遗传因素的一个重要候选基因。为了确定该特定基因在神经性厌食症（AN）易感性中的作用，我们检测了5-HTT基因启动子区域附近的一个串联重复序列，该序列有长（L）和短（S）两种变体。先前的研究表明，这两个等位基因之间5-HTT基因的转录活性存在显著差异。对一组138名符合《精神疾病诊断与统计手册》（DSM-IV）标准的AN患者和90名对照者进行了5-HTT基因连锁多态性（5-HTTLPR）基因分型。统计分析表明，两组之间的等位基因或基因型频率没有显著差异。这些数据表明，在我们的人群中，5-HTTLPR基因型与AN易感性之间没有关联。《美国医学遗传学杂志》（神经精神遗传学）96:53 - 55，2000年。
