Rieux C, Lee K, Lavaud A, Bierling P
Unité de Médecine Transfusionnelle et d'Hémovigilance, Hôpital Henri-Mondor, Créteil.
Ann Med Interne (Paris). 1999 Dec;150(8):631-41.
Although a number of research have been realized in the aim of decreasing the use of platelet concentrates, these blood products remain absolutely necessary for patients with therapeutic aplasia and for some surgical patients. After the description of the main rules of platelet transfusion procedures, we will discuss some controversial issues: threshold value for platelet transfusion, platelet doses, place of curative and prophylactic strategies, refractoriness to platelet transfusion, HLA alloimmunization. Then we will focus our review on the future alternatives for platelet transfusion.
尽管已经开展了多项旨在减少血小板浓缩物使用的研究,但这些血液制品对于治疗性再生障碍患者和一些外科手术患者而言仍然是绝对必要的。在描述了血小板输注程序的主要规则之后,我们将讨论一些有争议的问题:血小板输注的阈值、血小板剂量、治疗性和预防性策略的应用、对血小板输注的抵抗性、HLA同种免疫。然后我们将在综述中重点关注血小板输注的未来替代方案。