Predanic M
Department of Obstetrics and Gynecology, Flushing Hospital Medical Center, Flushing, New York 11355, USA.
Fertil Steril. 2000 Mar;73(3):522-5. doi: 10.1016/s0015-0282(99)00554-3.
To determine whether serum CA-125 and serial beta-hCG levels can be used to distinguish between tubal abortion and viable ectopic pregnancy (EP).
Retrospective cohort study.
A tertiary care institution.
PATIENT(S): Twenty-six women with EPs of 7-12 weeks' duration were studied retrospectively. Five had laparoscopically proved tubal abortions and 21 had active, viable EPs at the time of entry into the study. All but 3 of the latter group were managed surgically; the others were given a single dose of methotrexate.
INTERVENTION(S): Surgical removal of EPs by means of laparoscopy or laparotomy, or medical treatment of the disease.
MAIN OUTCOME MEASURE(S): Serum CA-125 and beta-hCG determinations were used to differentiate tubal abortion and viable EP. The results were compared with the findings at surgery.
RESULT(S): The mean (+/-SD) CA-125 level was 112.2 +/- 11.9 IU/mL for the patients with tubal abortion and 30.1 +/- 15.3 IU/mL for the patients with viable EP. The mean (+/-SD) beta-hCG level was 3,643 +/- 3,718 IU/L for the patients with tubal abortion and 10,755 +/- 11,465 IU/L for the patients with viable EP. Linear regression analysis showed a statistically insignificant inverse relation between serum CA-125 and beta-hCG levels.
CONCLUSION(S): The use of CA-125 levels as an adjunct to serial beta-hCG levels shows promise as a means for differentiating tubal abortion from viable EP.
确定血清CA - 125和连续β - hCG水平是否可用于区分输卵管流产和存活的异位妊娠(EP)。
回顾性队列研究。
一家三级医疗机构。
对26例妊娠7 - 12周的异位妊娠女性进行回顾性研究。5例经腹腔镜证实为输卵管流产,21例在进入研究时为活跃、存活的异位妊娠。后一组中除3例以外均接受手术治疗;其余患者给予单剂量甲氨蝶呤。
通过腹腔镜或剖腹手术手术切除异位妊娠组织,或对该疾病进行药物治疗。
采用血清CA - 125和β - hCG测定来区分输卵管流产和存活的异位妊娠。将结果与手术 findings进行比较。
输卵管流产患者的平均(±标准差)CA - 125水平为112.2±11.9 IU/mL,存活异位妊娠患者为30.1±15.3 IU/mL。输卵管流产患者的平均(±标准差)β - hCG水平为3643±3718 IU/L,存活异位妊娠患者为10755±11465 IU/L。线性回归分析显示血清CA - 125和β - hCG水平之间存在统计学上无显著意义的负相关。
将CA - 125水平作为连续β - hCG水平的辅助手段,有望成为区分输卵管流产和存活异位妊娠的一种方法。