Keiding S, Hansen S B, Rasmussen H H, Gee A, Kruse A, Roelsgaard K, Tage-Jensen U, Dahlerup J F
Arhus Universitetshospital, medicinsk afdeling V.
Ugeskr Laeger. 2000 Feb 7;162(6):782-5.
Primary sclerosing cholangitis (PSC) predisposes to cholangiocarcinoma (CC). PET scanning can assess metabolism in vivo. The glucose analogue [18 F]fluoro-2-deoxy-D-glucose (FDG) accumulates in malignant tumours because of high glucose metabolism. PET scanning of the liver was performed after intravenous FDG in nine patients with PSC, six with PSC + CC, and five controls. "Hot spots" with radioactivity accumulation were seen in each PSC + CC patient, but not in the two other groups. Values of net metabolic clearance of FDG, K (ml min-1 100 ml-1 tissue), was in CC hot spots 1.59 to 4.17 (median, 2.34; n = 6); in reference liver tissues of these patients 0.40 to 0.69 (0.49); in PSC 0.23 to 0.53 (0.36); in controls 0.20 to 0.34 (0.31). The difference between K in CC hot spots and the other groups was statistically significant (P < 0.001). FDG-PET may detect small CC tumours and be useful in therapeutic management of PSC.
原发性硬化性胆管炎（PSC）易患胆管癌（CC）。正电子发射断层扫描（PET）可在体内评估代谢情况。葡萄糖类似物[18F]氟-2-脱氧-D-葡萄糖（FDG）由于高糖代谢而在恶性肿瘤中蓄积。对9例PSC患者、6例PSC + CC患者和5例对照者静脉注射FDG后进行肝脏PET扫描。在每例PSC + CC患者中均可见放射性蓄积的“热点”，但在其他两组中未见。FDG的净代谢清除率K值（ml·min-1·100 ml-1组织）在CC热点为1.59至4.17（中位数，2.34；n = 6）；在这些患者的对照肝脏组织中为0.40至0.69（0.49）；在PSC患者中为0.23至0.53（0.36）；在对照者中为0.20至0.34（0.31）。CC热点的K值与其他组之间的差异具有统计学意义（P < 0.001）。FDG-PET可能检测到小的CC肿瘤，并有助于PSC的治疗管理。
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